Tumor Glomus

Putu Erika Paskarani; Ni Wayan Winarti

doi:10.15562/medicina.v51i2.977

Tumor Glomus

Putu Erika Paskarani ,

Ni Wayan Winarti ,

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DOI: https://doi.org/10.15562/medicina.v51i2.977 |
Published: 2020-02-05

Abstract

Glomus tumors are a very rare mesenchymal neoplasm, it happen less than 2% of all soft tissue tumors. It can be benign, borderline and malignant. The most common location were subungual, however it also can grow at the body organ and extremities. A 60-year-old male patient with firmly defined 1,5 cm diameters tumor mass at the proximal 1/3 proximal cruris region. He was complaining long history of pain and it spreading from the lesion area to the sole of the foot in the last 1 year occasionally. The pain improves at rest. An excisional biopsy was performed with macroscopic features of rounded tissueÂ gray-white color and tender. On microscopic examination, there are neoplastic cell proliferation arranged in a solid pattern, with spherical cell morphology, amphophilic to eosinophilic cytoplasm with spherical nucleus in the middle without atypical nuclear sign. Besides that, there is focal area of stromal hyalinization. No visible mitosis. Based clinical and histopathology feature, the patient is diagnosed as a glomus tumor. The prognosis is quite good because the location and size of the tumor allowing for complete surgical excision and the possibility of recurrence are very rare.

Tumor glomus merupakan neoplasma mesenkimal yang sangat jarang, hanya kurang dari 2% dari seluruh tumor jaringan lunak. Tumor ini dapat bersifat jinak, borderline dan ganas. Lokasi tumor tersering adalah di subungual namun dapat juga terjadi di organ dalam maupun ekstremitas. Pasien laki-laki, 60 tahun dengan massa tumor ukuran diameter 1,5 cm berbatas tegas pada regio cruris dekstra 1/3 proksimal, mengeluh nyeri timbul saat sentuhan dan terkadang menjalar dari daerah lesi ke telapak kaki sejak 1 tahun terakhir. Nyeri tersebut membaik saat istirahat. Telah dilakukan biopsi eksisi pada tumor tersebut dengan gambaran makroskopisjaringan berbentuk bulat, warna putih abu-abu dan kenyal ukuran 0,8 Ã— 0,7 Ã— 0,3cm. Pada pemeriksaan mikroskopis ditemukan proliferasi sel neoplastik yang membentuk pola solid, dengan morfologi sel bentuk bulat, sitoplasma amphofilik sampai eosinofilik dan inti bulat di tengah tanpa tanda atipia inti. Di sekitar sel tumor tampak fokus stroma yang mengalami hialinisasi. Tidak tampak mitosis. Pasien di diagnosis sebagai tumor glomus. Prognosis pasien ini baik karena lokasi dan ukuran tumor yang memungkinkan untuk dilakukan eksisi pembedahan dan kemungkinan terjadinya rekurensi sangat jarang.

References

Folpe A.L, Brems H, Legius E, Young R.H. WHO Classification of Tumours of Soft tissue and bone,4th Edition. Glomus Tumor. Lyon: IARC Press;2013. p. 116-117.
Lui T.H, Mak S.M. Glomus Tumor of the Great Toe.The journal of foot and ankle surgery, Elsevier.2014;53:360-363
Mravic M, LaChaud G, Nguyen A, Scott M.A, Sarah M, et al. Clinical and Histhopathological Diagnosis of Glomus Tumor: An Instituional Experience of 138 cases. International Surgical Pathology Journal. Vol 23, No.3:2015.p181-188
Liu K.L, Wang H.P, Tseng W.Y, Shun C.T, Chen J.S, et al. Glomus Tumor of The Stomach; MRI Findings, American Rontgen Ray Society Journal , Vol.185, p. 1190â€“1192.
Gombos Z.MD, Fogt F.MD, Zhang P.J,MD. Intraosseus glomus tumor of the great toe: A Case report with review of the literature. American college of foot and ankle surgeons journal.Vol 47, No.4:2008.p 299-301
Singh D, Garg R.S, Vikas, Yashika G, Arora V. Glomus tumor - a rarity; MRI -a big help in early diagnosis. Journal of orthopaedic case report. Vol 6, No.3:2016.p38-39
Lee J,MD, Yoo Y.M,MD, Lim H, MD, Park M.C, MD. Glomus tumor of the back: a rare location. The Journal of Craniofacial Surgery. Vol 20, No.6:2009.p 2153-2155
Weis S.W,MD, Goldblum J.R,MD. Enzinger and Weiss's Soft Tissue Tumor Volume 2, Fifth edition,USA:Elsevier; 2008.p 751-766.
Baral R, Limbu H. Glomus Tumor of Uncertain Malignant Potential. Journal of Pathology of Nepal. Vol. 1: 2011: p 66-68.
Goldblum J.R,MD, Mckenny J.K,MD, Myers J.L,MD, Glomus Tumor. Rosai and Ackerman's Surgical Pathology, Volume 2, Eleventh Edition.USA: Elsevier; 2016.p 1867-1868.

[1] Folpe A.L, Brems H, Legius E, Young R.H. WHO Classification of Tumours of Soft tissue and bone,4th Edition. Glomus Tumor. Lyon: IARC Press;2013. p. 116-117.

[2] Lui T.H, Mak S.M. Glomus Tumor of the Great Toe.The journal of foot and ankle surgery, Elsevier.2014;53:360-363

[3] Mravic M, LaChaud G, Nguyen A, Scott M.A, Sarah M, et al. Clinical and Histhopathological Diagnosis of Glomus Tumor: An Instituional Experience of 138 cases. International Surgical Pathology Journal. Vol 23, No.3:2015.p181-188

[4] Liu K.L, Wang H.P, Tseng W.Y, Shun C.T, Chen J.S, et al. Glomus Tumor of The Stomach; MRI Findings, American Rontgen Ray Society Journal , Vol.185, p. 1190â€“1192.

[5] Gombos Z.MD, Fogt F.MD, Zhang P.J,MD. Intraosseus glomus tumor of the great toe: A Case report with review of the literature. American college of foot and ankle surgeons journal.Vol 47, No.4:2008.p 299-301

[6] Singh D, Garg R.S, Vikas, Yashika G, Arora V. Glomus tumor - a rarity; MRI -a big help in early diagnosis. Journal of orthopaedic case report. Vol 6, No.3:2016.p38-39

[7] Lee J,MD, Yoo Y.M,MD, Lim H, MD, Park M.C, MD. Glomus tumor of the back: a rare location. The Journal of Craniofacial Surgery. Vol 20, No.6:2009.p 2153-2155

[8] Weis S.W,MD, Goldblum J.R,MD. Enzinger and Weiss's Soft Tissue Tumor Volume 2, Fifth edition,USA:Elsevier; 2008.p 751-766.

[9] Baral R, Limbu H. Glomus Tumor of Uncertain Malignant Potential. Journal of Pathology of Nepal. Vol. 1: 2011: p 66-68.

[10] Goldblum J.R,MD, Mckenny J.K,MD, Myers J.L,MD, Glomus Tumor. Rosai and Ackerman's Surgical Pathology, Volume 2, Eleventh Edition.USA: Elsevier; 2016.p 1867-1868.

Tumor Glomus

Abstract

References

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