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Serial kasus: Giant cell tumor di lokasi yang jarang

Abstract

Giant cell tumor (GCT) merupakan tumor tulang yang umum ditemukan pada orang dewasa berumur 20-50 tahun dengan lokasi tersering yaitu epifisis tulang panjang. Adapun predileksi lainnya yang jarang ditemukan seperti pada pelvis dan manus dengan insidensi 1,5-6,1 % di pelvis dan hanya 1-4% pada manus. Tiga orang wanita berusia 15 tahun, 34 tahun dan 26 tahun mengeluhkan muncul benjolan yang nyeri pada pelvis, jari tengah tangan kiri dan pergelangan tangan kiri. Pada pemeriksaan radiologi konvensional secara umum ditemukan lesi litik ekspansil bersepta dengan penipisan korteks pada regio tersebut dan dicurigai GCT. Biopsi telah mengkonfirmasi lesi-lesi tersebut adalah GCT. Adanya GCT pada lokasi yang jarang dilaporkan mempunyai angka kekambuhan yang tinggi. Foto polos merupakan modalitas yang murah dan mudah dilakukan untuk mendapatkan gambaran khas GCT, namun CT dan MRI dapat dilakukan tidak hanya untuk konfirmasi diagnosis namun untuk melihat perluasan tumor dan apakah adanya tanda-tanda malignansi.

 

Giant cell tumor (GCT) is a bone tumor generally found in young adults age 20-50 years-old where the frequent location for this tumor is epiphysis of the long bone. Other rare predilections for this tumor are pelvic also hands with an incidence in the pelvic bone are 1.5-6.1% and 1-4% in the hands. Three women at the age of 15, 34, and 26 years- old are complaining of painful lumps in her pelvic bone, 3rd finger of the left hand, and the left wrist. Radiology conventional examination shows a lytic expansile septated lesion with cortex thinning in those regions and suspected of having GCT. Biopsies of the lumps were taken and confirmed that the lesions were GCT. GCT found in rare places is reported to have a higher recurrence rate. Conventional radiographs are a quick and easy examination for diagnosis GCT, but CT scan and MRI can give more information about the lesions, their expansion, and if there are signs of malignancies

References

  1. Bajracharya, S., Khanal, G.P., Nepal, P., Shrestha, B.P., Singh, M. 2009. Giant Cell Tumor of Distal End Femur: A Challenge in Treatment. Acta Ortop Bras 17(2):58-61
  2. Balke, M., Schremper, L., Gebert, C. 2008. Giant cell tumor of bone: treatment and outcome of 214 cases. J Cancer Res Clin Oncol 134(9):969–978.
  3. Bridge, J.A., Neff, J.R., Mouron, B.J. 1992. Giant cell tumor of bone. Chromosomal analysis of 48 specimens and review of the literature. Cancer Genet Cytogenet. 58(1): 2–13.
  4. Barquin, P.G., Muruzabal, M.M., Aqueretta, J.D., Julian, M.S., Solorzano, J.L. 2015. Radiological and histopathological appearance of giant cell tumour of bone before and after the different therapeutic strategies. ESR 1-28
  5. Cavanna, L., Biasini, C., Monfredo, M., Maniscalco, P., Mori, M. 2014. Giant cell tumor of bone. Oncologist 19(11): 1207.
  6. Chakarun, C.J., Forrester, D.M., Gottsegen, C.J., Patel, D.B., White, E.A. 2013. Giant Cell Tumor of Bone: Review, Mimics, and New Developments in Treatment. RSNA 13(1): 197-2011.
  7. Jeys, L.M., Suneja, R., Chami, G., Grimer, R.J., Carter, S.R., Tillman, R.M. 2006. Impending fractures in giant cell tumours of the distal femur: incidence and outcome. Int Orthop 30(2):135-8.
  8. Reid, R., Banerjee, S.S., Sciot, R. 2002. Giant cell tumour. In: Fletcher CDM, Unni KK, Mertens F, eds. Pathology and Genetics of Tumors of Soft Tissue and Bone. Lyon: IARC Press, 309–313.
  9. Sobti, A., Agrawal, P., Agarwala, S., Agarwal, M. 2016. Giant Cell Tumor of Bone - An Overview. Arch Bone Jt Surg 4(1): 2-9.
  10. Szendröi, M. 2004. Giant-Cell Tumor of Bone. J Bone Joint Surg 86-B: 5-12.

How to Cite

Trisnawati, I. G. A., & Martadiani, E. D. (2020). Serial kasus: Giant cell tumor di lokasi yang jarang. Medicina, 51(3). https://doi.org/10.15562/medicina.v51i3.937

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I Gusti Ayu Trisnawati
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Pubmed
Medicina Journal


Elysanti Dwi Martadiani
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Pubmed
Medicina Journal