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Water-soluble Fullerene (C60) as The Reactive Oxygen Species Scavenger in Preventing Further Degeneration in Patients with Osteoarhtritis



Abstract

Background: Osteoarthritis (OA) is the most common degenerative disease that may contribute in the joints among population. Reactive oxygen species (ROS) is one of the main indicators that may affect the progression of OA itself. The current treatments are entangling physical measures, drug therapy, and surgery. The sphere carbon component call C60 Fullerene thought can be the breakthrough therapeutic management in treating OA patients.

Method: Literature review is done by searching journals with “C60 fullereneâ€, “osteoarthritisâ€, and “reactive oxygen species†on the search engines. From 49 journals that were reviewed, 47 were found suitable as reference for this paper.

Outcome: C60 fullerene is cage structured molecule consists of spherical carbon molecules. This derivate may work as the free radical scavenger that has high acting reactivity with ROS. C60 fullerene works by using several mechanisms that protects from main proinflammatory cytokines resulting from ROS expression, such as TNF-α and IL-1β. This modality works in several places, in the synoviocytes and also chondrocytes. Through its advantageous, there some setbacks including the difficult process regarding its nano molecule procedure and the questions marks regarding its safety and toxicity.

Conclusion: C60 fullerene may contribute in treating patients with OA through several mechanism of action. Further researches are required to identify the efficacy and effectivity of the C60 fullerene in treating OA patients and also its safety and toxicity.

 

Latar Belakang: Osteoarthritis (OA) merupakan suatu kondisi degenerative yang sering terjadi pada sendi manusia di seluruh dunia. Stress oksidatif (ROS) merupakan salah satu dari indikasi utama dalam progresivitas dan perkembangan dari OA itu sendiri. Pengobatan terkini dari OA meliputi rehabilitasi fisik, terapi obat, dan operasi. Terdapat sebuah komponen rantai hidrokarbon yang disebut C60 fullerene dinyatakan dapat menjadi suatu terobosan dalam pengobatan pada pasien dengan OA.

Metode: Artikel review ini diselesaikan dengan mencari kata kunci “C60 fullereneâ€, “osteoarthritisâ€, dan “reactive oxygen species†berbagai jurnal di beberapa mesin pencarian. Dari 49 jurnal yang ditemukan, didapatkan 47 jurnal tersebut cocok untuk dijadikan bahan dalam pembuatan artikel ini.

Hasil: Bahan hidrokarbon C60 fullerene ini merupakan rantai yang berbentuk bulat. Derivat ini dapat digunakan sebagai scavenger untuk stres oksidatif dengan reaktivitasnya yang tinggi terhadap stres oksidatif. C60 dapat bekerja melalui beberapa macam jalur yang dapat melindungi tubuh dari beberapa sitokin proinflamasi yang dihasilkan dari ekspresi stres oksidatif, seperti TNF-α dan IL-1β. Modalitas ini dapat bekerja pada beberapa tempat, seperti di synovial dan juga kondrosit. Terlepas dari kelebihannya, ada beberapa kekurangan dan limitasi yang perlu diperhatikan dari penggunaan nano molekul ini berhubungan dengan tingkat keamanan dan toksisitasnya.

Kesimpulan: C60 fullerene bisa berkontribusi dalam mengatasi pasien dengan OA melalui beberapa mekanisme kerja. Namun, penelitian lebih lanjut perlu dikembangkan untuk mengetahui secara pasti dari efektivitas C60 fullerene dalam mengatasi OA dan juga terkait keamanan dan toksisitasnya.

Keywords: C60 fullerene OA ROS

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How to Cite

Nolan, J., Karna, M. B., Asmara, A. G. Y., & Meregawa, P. F. (2020). Water-soluble Fullerene (C60) as The Reactive Oxygen Species Scavenger in Preventing Further Degeneration in Patients with Osteoarhtritis. Medicina, 51(2). https://doi.org/10.15562/medicina.v51i2.935
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John Nolan
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Made Bramantya Karna
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A.A. Gde Yuda Asmara
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Putu Feryawan Meregawa
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