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Hubungan antara profil lipid dengan derajat stenosis arteri koroner pada pasien penyakit jantung koroner stabil

Abstract

Abnormal lipid levels is a major contributor in atherosclerosis pathophysiology and a well-established risk factor for the development of coronary artery disease (CAD). In this study, we investigated correlation between lipid profile levels and degree of coronary artery stenosis in patient stable coronary artery disease. To study the associations of lipid biomarkers with coronary severity. We consecutively enrolled patients who underwent coronary angiography without previous lipid-lowering therapy in Sanglah General Hospital from June 2016 to May 2017. A total of 110 patients were enrolled in the present study, with male predominance (89 sample; 80.9%) and median age was 65 years old (89 sample; 80.9%). Regarding the lipid profile, 67 (60.9%) patients were observed to have total cholesterol kadar kolesterol total ≥ 200 mg/dL, 82 (74.5%) had LDL-C ≥ 130 mg/dL, 61 (55.5%) had TG  ≥ 150 mg/dL, 59 (53.6%) had HDL-C < 40 mg/dL, and  78 (70.9%) had non-HDL-C ≥ 152 mg/dL. The analysis of coronary angiographies showed 35 (31.8%) had low Gensini score and 75 (68.2%) had high Gensini score. In the bivariate analysis by Pearson correlation, the plasma TC levels (PR 6.43; p = 0.0001; LDL-C levels (PR 3.34; p = 0.009), and non-HDL-C (PR 5.66; p 0.0001) were positively associated with coronary stenosis severity. No statistically significant correlation between TG levels (PR 0.64; p=0.19) and HDL-C levels (PR 0.57; p=0.26) with coronary stenosis severity. Our data support the use of total cholesterol, LDL-C, and non-HDL-C in predicting the severity of coronary atherosclerosis

 

Kadar lipid yang abnormal dalam darah merupakan kontributor mayor dari patofisiologi atherosklerosis dan risiko penyakit jantung koroner (PJK). Pada studi ini diinvestigasi hubungan antara profil lipid dan derajat stenosis arteri koroner pada pasien PJK stabil yang belum mendapat terapi penurun lipid minimal 3 bulan sebelum penelitian. Penelitian potong lintang ini dilakukan di RSUP Sanglah Denpasar Bali dengan melibatkan 110 pasien PJK stabil yang dilakukan angiografi koroner pada periode bulan Juni 2016 sampai Mei 2017. Total sampel penelitian sebanyak 110, mayoritas adalah laki-laki (80.9%). Median usia sampel adalah 56 tahun. Sampel yang memiliki kadar kolesterol total ≥ 200 mg/dL sebanyak 67 orang (60.9%), kolesterol LDL ≥ 130 mg/dL 82 orang (74.5%), trigliserida ≥ 150 mg/dL 61 orang (55.5%), kolesterol HDL < 40 mg/dL 59 orang (53.6%), dan kolesterol non-HDL ≥ 152 mg/dL 78 orang (70.9%). Derajat stenosis arteri koroner dinilai berdasarkan skor Gensini dimana 35 sampel memiliki skor Gensini rendah (31.8%) dan 75 sampel memiliki skor Gensini tinggi (68.2%). Hasil analisis bivariat menunjukkan hubungan yang signifikan secara statistik antara kolesterol total (RP 6.43, p = 0.0001, IK 95% 2.65-15.55), LDL (RP 3.34; p = 0.009; IK 95% 2.50-4.46), dan non-HDL (RP 5.66; p 0.0001; IK 95% 2.3 – 13.85) dengan derajat stenosis arteri koroner. Tidak ditemukan hubungan yang signifikan antara HDL (RP 0.57; p = 0.26; IK 95% 0.25-1.30 ) dan trigliserida ( RP 0.64; p=0.19; IK 95% 0.28-1.45) dengan derajat stenosis arteri koroner. Hasil penelitian ini mendukung penggunaan kadar kolesterol total, LDL, dan non-HDL dalam memprediksi derajat stenosis arteri koroner pada pasien PJK stabil.

References

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How to Cite

Desak Gede Widyawati, A.A Ayu Dwi Adelia Yasmin, & IGN Putra Gunadhi. (2021). Hubungan antara profil lipid dengan derajat stenosis arteri koroner pada pasien penyakit jantung koroner stabil . Medicina, 52(2), 132–136. https://doi.org/10.15562/medicina.v52i2.682

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Desak Gede Widyawati
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Pubmed
Medicina Journal


A.A Ayu Dwi Adelia Yasmin
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Medicina Journal


IGN Putra Gunadhi
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Pubmed
Medicina Journal