Risk factors for steroid resistant nephrotic syndrome in children
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- DOI: https://doi.org/10.15562/medicina.v50i1.67  |
- Published: 2019-02-18
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Nephrotic syndrome (NS) is one of the most frequent glomerular disease in children. NS is classified to steroid sensitive nephrotic syndrome (SSNS) and steroid resistant nephrotic syndrome (SRNS) and it can be differentiate by histopathology change. Histopathology examination do not routinely done because it is not available in some medical center. The aim of this study to determine risk factor from clinical and laboratory aspect for steroid resistant nephrotic syndrome.
This study is a case control analytic study carried out in Sanglah Hospital in the 2012-2016. The subjects are all children with SSNS and SRNS aged < 12 years. There were fourty two patients enrolled in this study. Fourteen subjects in the case group (SRNS) and twenty eight subjects in the control group (SSNS). Bivariate analysis revealed that hypertension was a risk factor for SRNS with p value p=<0.001, reduced GFR was also a risk factor for SRNS with OR 15;95%CI 1.54 to 146.02, p=0.011. Multivariate analysis revealed that reduced GFR and mild edemaÂ are risk factor for SRNS with p value and OR respectively (OR 14.24;95%CI 1.19 to 169.48, p=0.03 ; OR 18.75;95%CI 1.08 to 325.23, p=0.04). In nephrotic syndrome children, hypertension, reduce GFR and mild edema are the risk factor of steroid resistant Â nephrotic syndrome.