Diabetic foot is one of the complications of diabetes mellitus (DM) which is still giving problems such as ulcers or wounds that are difficult to cure, and even can cause gangrene and ultimately leading to amputation. There are several risk factors for amputation in patients with diabetic foot; such as high levels of HbA1C and long ulcer. This study is an observational study retrospective analytic by design a case control study with matching based on age and gender to looking for risk factors for amputation patients with diagnosis of diabetic foot in 76 patients who come to Sanglah General Hospital Denpasar. Data were analyzed using cross tabulation tables 2x2, and weâ€™ve got the odd ratio (OR) as a result. Â In this study, group of patients with amputations (cases) are 24 male (63.2%) and 14 women (36.8%), as well as in the control group (match). Lowest patient age is 40 years old and the highest 76 years, with an average age of 57.2 (SD 8.2) years. Further analysis of this study found that the long ulcers â‰¥ 3 months, OR 10.0 (95% IK 2.4 to 88.2; p = 0.0001), levels of HbA1c â‰¥ 6.5 with OR 20.0 (95% IK 3.1 to 828; p = 0.0000). Levels of HbA1C â‰¥ 6.5 and ulcer â‰¥ 3 months old are the risk factors for amputation in patients with diabetic foot.