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Abstract

Turner syndrome (TS), a disorder of female is characterized by the absence of all or part of second sex chromosome. TS is associated with amount of potensial abnormalities in many organ systems. Important to recognize a classical case of TS and its management. A 16 year old girl who was reffered with delay puberty, short stature and hearing loss. She had prepubertal pattern genital development, no distribution of axilary and pubic hair, high arch palatum, low posterior hair line, low set ears and short neck. Laboratory examination showed high consentration of lutein and follicular stimulating hormon, and low consentration of estradiol, with the karyotyping (45,XO). We planed to give growth hormone but it wasn’t covered by insurance. Low ethinylestradiol started with gradually increament and after 6 month therapy, she had minimal pubic hair and breast development, 0,5 cm height increment and got grommet insertion to treat the hearing loss. Recognizing TS in many organ systems was important to make a proper management.

 

References

  1. Saenger P., Bondy C.A. Turner syndrome. Pediatric endocrinology. Edition 4th. Elsavier: Philadhelpia. 2014, p :664-95
  2. Zhong quincy, layman Lawrence. Genetic consideration in the patient with turner syndrome- 45, X with or without mosaicism.
  3. Elsheikh M., Dunger DB., Conway DS., Wass JA., Turner syndrome in adulthood. Endoor Rev 2012, 23: 120-40
  4. Morgan T. Turner Syndrome diagnosis and management. American academy of family phycsician. 2007, 76: 405-10
  5. Sybert V. P., Clauley E.M., Turner syndrome. The new England journal of medicine.2009;351: 1227-38
  6. Bondy C. Recent development in diagnosis and care for girls in turner syndrome. Advance in endocrinology. 2014, p: 9
  7. Gonzalez luiza, witchel Selma, The patient with turner syndrome : puberty and medical management concerns. American society for reproductive medicine. 2012.
  8. Lucaccioni L., et al. Turner syndrome – issues to consider for transition to adulthood. British medical bulletin. 2015, 113: 45- 58.
  9. Alves C., Oliviera C. S. Hearing loss among patient with turner’s syndrome : literature review. Brazilian journal of otorhinolaryngology. 2014, 80: 257 – 263.
  10. Saenger P., et al. Recommendation for the diagnosis and management of turner syndrome. The journal of clinical endocrine and metabolism. 2011, 86 ; 3061 – 3069.
  11. Chandrashekhar T., Veena D., A classsical case of Turner Syndrome. International Journal of recent Trend in science and technology. 2014, 10: 231-232
  12. Meenakshi A., Shetty P., Kumari S., Nandan N. Female patient with a variant of turner syndrome. Nitte university journal of health science. 2014, 4: 2249-7110
  13. Chatelaine P., berlier P., Francois R. Pathology of ovary. Pediatric endocrinology physiology and clinical aspects. Edition-2nd. Williams and wilkins, 2009, p : 420-24.
  14. Conte Felix A., grumbach M.M. Abnormalities of sexual detemination of differentiation. Basic and clinical endocrinology. Edition-7th.McGraw-Hill.2008, p: 579-80.
  15. Labarta J. I., et al. Induvidualized vs fixed dose or oral 17β oestradiol for induction of puberty in gilrs with turner syndrome: open randomized parallel trial. European journal of endocrinology. 2012, 167 : 523- 529.
  16. Santiago L.T., et al. Metabolic effects of oral versus transdermal 17β estradiol(E2): A randomized clinical trial in girls with turner syndrome. J Clin Endocrinol Metab. 2013, 98 : 2716-2724.
  17. Ross J., et al., Growth hormone plus childhood low dose estrogen in turner syndrome. The new England journal of medicine. 2011, 364: 1230- 42
  18. Wilson T. A., et al. Update of guideline for the use of growth hormone in children. The Lawson wilkins pediatric endocrinology society drug and therapeutics committee. 2010
  19. Spiliotis. B.E. Recombinant human growth hormone in the treatment of turner syndrome. Therapeutics and risk management. 2008; 4 : 1177 – 1183.
  20. Solberg P.F., et al. Endocrine diseases, perspectives and care in turner syndrome. Arq bras endocinol metab. 2011, 55.
  21. Trolle C., et al. Sex hormone replacement in turner syndrome. Springer. 2012, 41: 200- 219.
  22. Hagman A., et al. Obstetric and neonatal outcome after oocyte donation in 106 women with turner syndrome: a Nordic cohort studi. Human reproduction journal, 2013.
  23. Gorman C. S., et al. An evaluation of early cardiometabolic risk factors in chikdren and adolescent with turner syndrome. Clinical endocrinology, 2013; 78: 907- 913.

How to Cite

Sari, L. S. (2018). A classical turner syndrome in 16 years old girl. Medicina, 49(3). https://doi.org/10.15562/medicina.v49i3.186

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