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Pemberian rivaroxaban menurunkan kadar D-dimer pada operasi fiksasi interna tulang panjang ekstremitas bawah

Abstract

Deep Vein Thrombosis (DVT), oftenly become post operative complication on long bone internal fixation procedure and might leading to high morbidity to patients. D-Dimer is a fibrin degradation product which may become accurate marker for DVT. This research purpose is to prove that administration of Rivaroxaban in lowering D-Dimer level post operatively after internal fixation of lower extremities long bone.

              This research  is pre post experimental test with double blind sampling which consist of 40 samples, which is divided into 2 groups contains  20 samples each. First group was given 10 mg Rivaroxaban per oral 6 - 10 hours post-operation, on the second group  was given placebo. D-Dimer level checked in 1 day pre-operative, 1 day post-operative and 3 days post-operative.

               D-Dimer  mean measured in Rivaroxaban group, pre-operative 0.54 mg/L, 1 day post-operative 1.17 mg/L, 3 days post-operative 1.03 mg/L. D-Dimer  Mean result in placebo group, pre-operative 0.77 mg/L, 1 day post-operative 5.74 mg/L, 3 days post-operative  3.89 mg/L. This research using independent t-Test in pre operative in both groups with no difference with significance of 0.07 (p>0.05), 1 day post operative with significance 0.002 (p<0.05) and on 3 days post-operative with significance 0.002 (p<0.05).

              This research proves that administration of Rivaroxaban decreasing D-Dimer level on lower extremities long bone internal fixation operation. This result support that Rivaroxabanas is an effective thromboprophylaxis medicamentosa to DVT.

 

 

 


 

How to Cite

Parama Bambie, R. B., Kawiyana, I. K. S., & Suyasa, I. K. (2018). Pemberian rivaroxaban menurunkan kadar D-dimer pada operasi fiksasi interna tulang panjang ekstremitas bawah. Medicina, 49(2). https://doi.org/10.15562/medicina.v49i2.168

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Raditya Bagus Parama Bambie
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Pubmed
Medicina Journal


I Ketut Siki Kawiyana
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Medicina Journal


I Ketut Suyasa
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Medicina Journal