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Lead contained in vehicle fumes are inhalated into lungs and  bound in the blood. Hematotoxic effects of lead was inhibit enzymes that involved in heme biosynthesis caused decreasing number of erythrocytes and hemoglobin of people who are exposed to lead. Vitamin C inhibit lead uptake, and reduce lead level in the blood because it reduce lead absorption in intestine. The purpose of this study was determined the supplementation of vitamin C  reduce level of lead and increase erythrocytes count and hemoglobin level of the street sweeper. Method of this study was pre test and post test control group design. The data collected from 30  women street sweeper. Subjects were divided in two group, with 15 women each. Control group were given placebo tablets, and treated group were given vitamin C tablet 250 mg for 30 days. Lead level were measured before and after treatment, analyzed by independent t-test. Hemoglobin level and erythrocyte count were measured before and after treatment were analyzed by Mann-Whitney Test. Result showed the mean of lead level  for control group was 1.413 SD 0.348 and treated group was 1.033 SD 0.324,  p = 0,034. Mean of erythrocyte of control group was 4.511 SD 0.349 and treated group was 4.744 SD 0.363, p = 0.765. Mean of hemoglobin levels of control group was 13.355 SD 0.605 and treated group was 13.352 SD 0.340, p= 0.665.  Reduction in lead level after given vitamin C were significantly (p <0.05) and no significant increase in  number of erythrocyte and hemoglobin level (p> 0.05).  It concluded that supplementation of vitamin C 250 mg per day reduced blood lead level . The results of this research can used to prevent lead poisoning for a street sweeper.




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How to Cite

Sundari, L. P. R. (2017). Pemberian vitamin C 250 mg per oral menurunkan kadar timbal darah wanita penyapu jalan di Kota Denpasar. Medicina, 48(3).




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