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Hubungan antara hitung eosinofil dengan sarkopenia pada lansia di Desa Melinggih, Kecamatan Payangan, Kabupaten Gianyar, Provinsi Bali

Abstract

Introduction: Every year, the number of elderly people rises, which can lead to a variety of age-related health issues. One of the effects of the aging process in the elderly is a change in body composition, especially a decrease in muscle mass. Decreased muscle mass and strength in the elderly are related to the occurrence of sarcopenia in the elderly. Chronic inflammation due to aging can cause disturbances in muscle regeneration, usually followed by a dysregulation of the immune response. One component involved in the immune system's main effector is eosinophils. The eosinophil count is affordable, available, and widely accessible and can reflect the inflammatory state. The purpose of this study is to ascertain whether eosinophil levels and sarcopenia in the elderly are related.

Methods: This research is an observational study with a cross-sectional study and conducted in Melinggih Village, Payangan District, Gianyar Regency, Bali Province, in October 2022. The sample in this study was elderly people (≥60 years) and was selected by consecutive sampling from the reachable population for the study.

Results: The total number of subjects in this study was 122 people, with a median age of 68.5 years, and the majority were women (54.1%). Most of the subjects' eosinophil counts were in the normal category (54.9%). More than half of the subjects had sarcopenia, namely 75 people (61.5%). Multivariate analysis performed showed that a high eosinophil count (p = 0.997) was not a risk factor for sarcopenia.

Conclusion: The eosinophil count has no significant association with sarcopenia in the elderly in Melinggih Village, Payangan District, Gianyar Regency, Bali Province.

 

Latar Belakang: Jumlah populasi lanjut usia (lansia) mengalami peningkatan tiap tahunnya dan dapat menimbulkan berbagai masalah kesehatan akibat adanya penuaan. Perubahan komposisi tubuh khususnya penurunan massa otot merupakan salah satu dampak dari proses penuaan pada lansia. Massa dan kekuatan otot yang menurun pada lansia kemudian dikaitkan dengan sarkopenia. Inflamasi kronis akibat penuaan dapat mengakibatkan gangguan pada regenerasi otot yang biasanya diikuti oleh disregulasi respon imun. Salah satu komponen yang terlibat dalam efektor utama sistem imun adalah eosinofil. Pemeriksaan hitung eosinofil terjangkau, tersedia, dan diakses secara luas dan dapat menggambarkan status inflamasi. Tujuan studi ini adalah untuk mengevaluasi hubungan antara hitung eosinofil dengan sarkopenia pada lansia.

Metode: Desain studi ini adalah cross-sectional yang dilakukan di Desa Melinggih, Kecamatan Payangan, Kabupaten Gianyar, Bali pada bulan Oktober 2022. Sampel pada penelitian ini merupakan lansia (≥60 tahun) dan dipilih secara consecutive sampling dari populasi terjangkau penelitian.

Hasil: Sebanyak 122 orang menjadi subjek penelitian, dengan median usia 68,5 tahun dan mayoritas adalah perempuan yaitu 66 orang (54,1%). Jumlah hitung eosinofil sebagian besar subjek berada dalam kategori normal (54,9%). Lebih dari setengah subjek mengalami sarkopenia, yaitu sebanyak 75 orang (61,5%). Analisis multivariat yang dilakukan menunjukkan bahwa hitung eosinofil yang tinggi (p = 0,997) bukan merupakan faktor risiko terhadap kejadian sarkopenia.

Simpulan: Hitung eosinofil tidak memiliki hubungan signifikan dengan sarkopenia pada lansia di Desa Melinggih, Kecamatan Payangan, Kabupaten Gianyar, Provinsi Bali.

References

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How to Cite

Ni Made Ratih Purnama Dewi, & Komang Ayu Vitriana Gamayanti. (2023). Hubungan antara hitung eosinofil dengan sarkopenia pada lansia di Desa Melinggih, Kecamatan Payangan, Kabupaten Gianyar, Provinsi Bali. Medicina, 54(3), 156–162. https://doi.org/10.15562/medicina.v54i3.1281

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Ni Made Ratih Purnama Dewi
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Komang Ayu Vitriana Gamayanti
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