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Kadar Cartilage Oligomeric Matrix Protein (COMP) dan Crosslinked C-Telopeptides of Type II Collagen (CTX II) Yang Tinggi Merupakan Faktor Risiko Terjadinya Sendi Lutut Tidak Stabil Pada 12 Bulan Pasca Rekonstruksi Anterior Cruciate Ligament

  • I Made Arya Susila ,
  • K G Mulyadi Ridia ,
  • I Gusti Ngurah Wien Aryana ,
  • A A Wiradewi Lestari ,
  • I Ketut Suyasa ,
  • Putu Astawa ,

Abstract

Introduction: Anterior Cruciate Ligament (ACL) tear is a common debilitating knee injury in young adults due to sports injuries. Failure to administer appropriate treatment led to continuous inflammatory response, marked with inflammatory mediator release, such as COMP and CTX-II. It may further provoke tissue damage and induce knee joint instability. The study aims to investigate the relationship between COMP and CTX-II levels in knee joint instability following an ACL reconstruction.

Methods: A case-control study with consecutive sampling was performed among 18 patients with 8 unstable knee joints following an ACL reconstruction at 12 months follow-up. The parameters assessed are knee joint instability with Lachmeter measurement, COMP levels from knee joint synovial fluid, and CTX-II from blood serum. Statistical analysis is performed using SPSS software.

Results: Most of the sample was male (66.67%) with an average age of 27.11 ± 9.59 years. This study showed a significant difference in COMP and CTX-II levels between the unstable joint and stable joint groups after anterior cruciate ligament reconstruction (p=0.005 and p=0.008). Chi-Square test showed that high levels of COMP and CTX-II were risk factors for knee joint instability at 12 months after ACL reconstruction (COMP OR 10.50; CI95% 0.90 – 121.38; p=0.04 and CTX-II 16.33; IK95% 1.34 – 197.76; p=0.015).

Conclusion: Elevated levels of COMP and CTX-II are applicable in predicting knee instability following ACL reconstruction at 12 months postoperatively.

 

Latar belakang: Robekan Anterior Cruciate Ligament (ACL) merupakan cedera lutut yang umum terjadi pada populasi usia muda. Kegagalan pengobatan yang tepat dapat menyebabkan respon inflamasi kronis dan kerusakan jaringan, sehingga menyebabkan ketidakstabilan sendi lutut. Respon inflamasi dapat ditandai dengan pelepasan mediator inflamasi, seperti Cartilage Oligomeric Matrix Protein (COMP) dan Crosslinked C-Telopeptides of Type II Collagen (CTX-II). Penelitian ini bertujuan untuk mengetahui hubungan antara kadar COMP dan CTX-II pada ketidakstabilan sendi lutut setelah rekonstruksi ACL.

Metode: Studi case-control dengan pengambilan sampel konsekutif dilakukan pada 18 pasien, dengan 8 pasien sendi lutut tidak stabil setelah rekonstruksi ACL pada 12 bulan masa follow-up. Pengukuran ketidakstabilan sendi lutut dilakukan dengan pengukuran Lachmeter, kadar COMP dan CTX-II diukur melalui cairan sinovial sendi lutut dan serum darah. Analisis statistik dilakukan dengan program SPSS v.26.

Hasil: Sebagian besar sampel adalah laki-laki (66,67%) dengan rata-rata usia 27,11±9,59 tahun. Pada penelitian ini terdapat perbedaan kadar COMP dan CTX-II yang signifikan antara kelompok sendi tidak stabil dan sendi stabil pasca rekonstruksi anterior cruciate ligament (p=0,005 dan p=0,008). Uji Chi Square menunjukkan tingkat COMP dan CTX-II yang tinggi merupakan faktor risiko ketidakstabilan sendi lutut pada 12 bulan setelah rekonstruksi ACL (COMP OR 10,50; IK95% 0,90 – 121,38; p=0,04 dan CTX-II 16,33; IK95% 1,34 – 197,76; p=0,015).

Kesimpulan: Peningkatan kadar COMP dan CTX-II merupakan faktor risiko yang signifikan terhadap ketidakstabilan lutut setelah rekonstruksi ACL pada 12 bulan pasca operasi.

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How to Cite

I Made Arya Susila, K G Mulyadi Ridia, I Gusti Ngurah Wien Aryana, A A Wiradewi Lestari, I Ketut Suyasa, & Putu Astawa. (2023). Kadar Cartilage Oligomeric Matrix Protein (COMP) dan Crosslinked C-Telopeptides of Type II Collagen (CTX II) Yang Tinggi Merupakan Faktor Risiko Terjadinya Sendi Lutut Tidak Stabil Pada 12 Bulan Pasca Rekonstruksi Anterior Cruciate Ligament. Medicina, 54(3), 153–157. https://doi.org/10.15562/medicina.v54i3.1263

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