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Pengaruh konsentrasi PM2.5 pada polusi udara terhadap kejadian demensia: tinjauan sistematis


The increasing number of people with dementia globally has given rise to studies examining the association of dementia with various risk factors. The researchers found evidence that for every 2 µg/m3 increase in mean annual PM2.5 concentration, the overall risk of dementia increased by 4% (hazard ratio 1.04 (95% confidence interval 0.99 to 1.09). PM2.5 concentrations in large cities vary widely, from under 10 µg/m3 to over 100 µg/m3. Therefore, air pollution has the potential to significantly influence the risk of dementia globally. Researchers used data from the PubMed database and ScienceDirect for epidemiological studies reporting the risk of developing dementia due to exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5). The selection of articles was carried out according to the PRISMA method to assess the quality of systematic reviews. The database search yielded 5 studies relevant which describe the relationship between exposure to PM2.5 air pollutants and an increased risk of dementia. Of the 85 articles reviewed, there were 5 related articles which proved that air pollution is a risk factor for dementia.


Jumlah penderita demensia yang kian meningkat secara global meningkatkan studi yang membahas hubungan demensia dengan berbagai faktor risiko. Para peneliti menemukan bukti untuk setiap peningkatan rata-rata konsentrasi PM2.5 tahunan sebesar 2 µg/m3, risiko demensia secara keseluruhan meningkat sebesar 4% (rasio bahaya 1,04 (interval kepercayaan 95% 0,99 hingga 1,09). Adapun konsentrasi PM2.5 di kota-kota besar sangat bervariasi, mulai dari di bawah 10 µg/m3 hingga lebih dari 100 µg/m3. Oleh karena itu, polusi udara berpotensi secara signifikan mempengaruhi risiko demensia secara global. Peneliti menggunakan data dari basis data PubMed dan ScienceDirect untuk studi epidemiologi yang melaporkan risiko pengembangan penyakit demensia akibat paparan materi partikulat dengan diameter aerodinamis kurang dari 2,5 μm (PM2.5). Pemilihan artikel dilakukan sesuai dengan metode PRISMA untuk menilai kualitas dari tinjauan sistematis. Penelusuran basis data menghasilkan 5 penelitian relevan yang menggambarkan hubungan antara paparan polutan udara PM2.5 dengan peningkatan risiko demensia. Dari 85 artikel yang direview, terdapat 5 artikel terkait yang membuktikan bahwa polusi udara merupakan faktor risiko kejadian demensia


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How to Cite

Kawi, Y. A., Diatmika, I. P. ., Mahardika, A. ., Diniari, N. K. S. ., & Satyarsa, A. B. S. (2023). Pengaruh konsentrasi PM2.5 pada polusi udara terhadap kejadian demensia: tinjauan sistematis. Medicina, 54(1), 38–43.




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