Kombinasi Parasetamol dan Ibuprofen Untuk Nyeri Punggung Bawah Akut: Sebuah Tinjauan Sistematik Mini

Putu Eka Widyadharma; Eric Hartono Tedyanto; Anak Agung Ayu Putri Laksmidewi; I Made Oka Adnyana; Dewa Putu Gde Purwa Samatra

doi:10.15562/medicina.v52i3.1067

Kombinasi Parasetamol dan Ibuprofen Untuk Nyeri Punggung Bawah Akut: Sebuah Tinjauan Sistematik Mini

Putu Eka Widyadharma ,

Eric Hartono Tedyanto ,

Anak Agung Ayu Putri Laksmidewi ,

I Made Oka Adnyana ,

Dewa Putu Gde Purwa Samatra ,

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DOI: https://doi.org/10.15562/medicina.v52i3.1067 |
Published: 2021-09-01

Abstract

Latar Belakang: Nyeri punggung bawah merupakan salah satu masalah kesehatan yang paling umum terjadi, dengan prevalensi secara global sekitar 38,9%. Konsep politerapi untuk analgesik sering digunakan dalam terapi nyeri. Hal ini berarti menambahkan satu jenis obat lain yang memiliki efek tambahan atau sinergisitas dengan obat anti nyeri yang utama, dengan meminimalisasi efek samping dari obat.

Metode: Kami melakukan pencarian secara sistematik melalui PubMed dan Embase sesuai dengan protokol yang telah dibuat oleh PRISMA dalam melakukan tinjauan sistematik. Satu orang peninjau mengambil data dari artikel yang telah terpilih. Data yang akan diambil adalah populasi studi, desain studi, jenis intervensi yang dilakukan, variabel kontrol, dan hasil kesimpulan dari penelitian

Hasil: Kami menemukan 56 jurnal pada strategi pencarian kami. Pada akhirnya, terdapat 2 studi yang memenuhi kriteria kelayakan dan dimuat dalam tinjauan sistematik ini. Kedua studi menyatakan bahwa penggunaan kombinasi parasetamol dan ibuprofen (OAINS) memiliki efek yang lebih superior dibanding monoterapi.

Kesimpulan: Kombinasi parasetamol dan ibuprofen dapat dipertimbangkan untuk diberikan sebagai terapi anti nyeri pada nyeri punggung bawah akut mengingat efek anti nyeri yang bagus dan efek samping yang minimal.

References

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Rapoport J, Jacobs P, Bell NR, Klarenbach S. Refining the measurement of the economic burden of chronic diseases in Canada. Chronic Dis Can. 2004. 25(1):13-21.
Enthoven WTM, Roelofs PDDM, Deyo RA, van Tulder MW, Koes BW. Non-steroidal anti-inflammatory drugs for chronic low back pain. Cochrane Database of Systematic Reviews. 2016. 10;2(2) doi: 10.1002/14651858
van der Gaag WH, Roelofs PDDM, Enthoven WTM, van Tulder MW, Koes BW. Non-steroidal anti-inflammatory drugs for acute low back pain. Cochrane Database of Systematic Reviews. 2020. 16;4(4). doi: 10.1002/14651858
Eccleston C, Cooper TE, Fisher E, Anderson B, Wilkinson NMR. Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. Cochrane Database of Systematic Reviews. 2017. Volume 2. doi: 10.1002/14651858.CD012537
Saragiotto BT, Machado GC, Ferreira ML, Pinheiro MB, Abdel Shaheed C, Maher CG. Paracetamol for low back pain. Cochrane database Syst Rev. 2016; Volume 6. doi: 10.1002/14651858.CD012230
Hung KKC, Graham CA, Lo RSL, Leung YK, Leung LY, Man SY, et al. Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial. PLoS One. 2018; 6;13(2):e0192043. doi: 10.1371/journal.pone.0192043.
Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, et al. Combined and alternating paracetamol and ibuprofen therapy for febrile children. Evidence-Based Child Health. 2014. 013(10):CD009572. doi: 10.1002/14651858.CD009572.pub2.
Nikose S, Khan S, Gudhe M, Patil B, Singh P. Efficacy of Diclofenac Versus Combination of Ibuprofen and Paracetamol, in Acute Low Back Pain With Sciatica.. 2016;3(12):487–91.
Ostojic P, Radunovic G, Lazovic M, Tomanovic-Vujadinovic S. Ibuprofen plus paracetamol versus ibuprofen in acute low back pain: A randomized open label multicenter clinical study. Acta Reumatol Port. 2017; 38(3): 284–291. doi: 10.15537/smj.2017.3.16023
Schnitzer TJ, Ferraro A, Hunsche E, Kong SX. A comprehensive review of clinical trials on the efficacy and safety of drugs for the treatment of low back pain. Journal of Pain and Symptom Management. 2004. 28(1):72-95. doi: 10.1016/j.jpainsymman.2003.10.015.
Moore RA, Chi CC, Wiffen PJ, Derry S, Rice ASC. Oral nonsteroidal anti-inflammatory drugs for neuropathic pain. Cochrane Database of Systematic Reviews. 2015(10):CD010902. doi: 10.1002/14651858.CD010902.pub2.
Wongrakpanich S, Wongrakpanich A, Melhado K, Rangaswami J. A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly. Aging and Disease. 2018. 9(1): 143–150. doi: 10.14336/AD.2017.0306
Sjoukes A, Venekamp RP, van de Pol AC, Hay AD, Little P, Schilder AGM, et al. Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. Cochrane Database of Systematic Reviews. 2016. 12(12):CD011534. doi: 10.1002/14651858.CD011534.pub2.
Machado GC, Maher CG, Ferreira PH, Pinheiro MB, Lin CWC, Day RO, et al. Efficacy and safety of paracetamol for spinal pain and osteoarthritis: Systematic review and meta-analysis of randomised placebo controlled trials. BMJ (Online). 2015. 350:h1225. doi: 10.1136/bmj.h1225.
Beverly A, Kaye AD, Ljungqvist O, Urman RD. Essential Elements of Multimodal Analgesia in Enhanced Recovery After Surgery (ERAS) Guidelines. Anesthesiology Clinics. 2017. 35(2):e115-e143. doi: 10.1016/j.anclin.2017.01.018.
Gritsenko K, Khelemsky Y, Kaye AD, Vadivelu N, Urman RD. Multimodal therapy in perioperative analgesia. Best Practice and Research: Clinical Anaesthesiology. 2014. 28(1):59-79. doi: 10.1016/j.bpa.2014.03.001.
Ong CKS, Seymour RA, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: A qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010; 110(4):1170-9. doi: 10.1213/ANE.0b013e3181cf9281.

[1] Hoy D, Bain C, Williams G, March L, Brooks P, Blyth F, et al. A systematic review of the global prevalence of low back pain. Arthritis and Rheumatism. 2012. 64(6):2028-37. doi: 10.1002/art.34347

[2] Rapoport J, Jacobs P, Bell NR, Klarenbach S. Refining the measurement of the economic burden of chronic diseases in Canada. Chronic Dis Can. 2004. 25(1):13-21.

[3] Enthoven WTM, Roelofs PDDM, Deyo RA, van Tulder MW, Koes BW. Non-steroidal anti-inflammatory drugs for chronic low back pain. Cochrane Database of Systematic Reviews. 2016. 10;2(2) doi: 10.1002/14651858

[4] van der Gaag WH, Roelofs PDDM, Enthoven WTM, van Tulder MW, Koes BW. Non-steroidal anti-inflammatory drugs for acute low back pain. Cochrane Database of Systematic Reviews. 2020. 16;4(4). doi: 10.1002/14651858

[5] Eccleston C, Cooper TE, Fisher E, Anderson B, Wilkinson NMR. Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. Cochrane Database of Systematic Reviews. 2017. Volume 2. doi: 10.1002/14651858.CD012537

[6] Saragiotto BT, Machado GC, Ferreira ML, Pinheiro MB, Abdel Shaheed C, Maher CG. Paracetamol for low back pain. Cochrane database Syst Rev. 2016; Volume 6. doi: 10.1002/14651858.CD012230

[7] Hung KKC, Graham CA, Lo RSL, Leung YK, Leung LY, Man SY, et al. Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial. PLoS One. 2018; 6;13(2):e0192043. doi: 10.1371/journal.pone.0192043.

[8] Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, et al. Combined and alternating paracetamol and ibuprofen therapy for febrile children. Evidence-Based Child Health. 2014. 013(10):CD009572. doi: 10.1002/14651858.CD009572.pub2.

[9] Nikose S, Khan S, Gudhe M, Patil B, Singh P. Efficacy of Diclofenac Versus Combination of Ibuprofen and Paracetamol, in Acute Low Back Pain With Sciatica.. 2016;3(12):487–91.

[10] Ostojic P, Radunovic G, Lazovic M, Tomanovic-Vujadinovic S. Ibuprofen plus paracetamol versus ibuprofen in acute low back pain: A randomized open label multicenter clinical study. Acta Reumatol Port. 2017; 38(3): 284–291. doi: 10.15537/smj.2017.3.16023

[11] Schnitzer TJ, Ferraro A, Hunsche E, Kong SX. A comprehensive review of clinical trials on the efficacy and safety of drugs for the treatment of low back pain. Journal of Pain and Symptom Management. 2004. 28(1):72-95. doi: 10.1016/j.jpainsymman.2003.10.015.

[12] Moore RA, Chi CC, Wiffen PJ, Derry S, Rice ASC. Oral nonsteroidal anti-inflammatory drugs for neuropathic pain. Cochrane Database of Systematic Reviews. 2015(10):CD010902. doi: 10.1002/14651858.CD010902.pub2.

[13] Wongrakpanich S, Wongrakpanich A, Melhado K, Rangaswami J. A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly. Aging and Disease. 2018. 9(1): 143–150. doi: 10.14336/AD.2017.0306

[14] Sjoukes A, Venekamp RP, van de Pol AC, Hay AD, Little P, Schilder AGM, et al. Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. Cochrane Database of Systematic Reviews. 2016. 12(12):CD011534. doi: 10.1002/14651858.CD011534.pub2.

[15] Machado GC, Maher CG, Ferreira PH, Pinheiro MB, Lin CWC, Day RO, et al. Efficacy and safety of paracetamol for spinal pain and osteoarthritis: Systematic review and meta-analysis of randomised placebo controlled trials. BMJ (Online). 2015. 350:h1225. doi: 10.1136/bmj.h1225.

[16] Beverly A, Kaye AD, Ljungqvist O, Urman RD. Essential Elements of Multimodal Analgesia in Enhanced Recovery After Surgery (ERAS) Guidelines. Anesthesiology Clinics. 2017. 35(2):e115-e143. doi: 10.1016/j.anclin.2017.01.018.

[17] Gritsenko K, Khelemsky Y, Kaye AD, Vadivelu N, Urman RD. Multimodal therapy in perioperative analgesia. Best Practice and Research: Clinical Anaesthesiology. 2014. 28(1):59-79. doi: 10.1016/j.bpa.2014.03.001.

[18] Ong CKS, Seymour RA, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: A qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010; 110(4):1170-9. doi: 10.1213/ANE.0b013e3181cf9281.

Kombinasi Parasetamol dan Ibuprofen Untuk Nyeri Punggung Bawah Akut: Sebuah Tinjauan Sistematik Mini

Abstract

References

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